Glossary

Reference: Wikipedia (www.wikipedia.com

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Nitric oxide

is a signaling molecule produced by the body that helps the body cells to communicate. It signals the body to release more blood to the organs when needed. One of the common ways to increase the concentration of NO in the body is through exercise. While working out, body muscles need more oxygen, which is supplied with blood. The heart pumps with high pressure to supply sufficient blood to the muscles; the lining of the arteries releases NO into the blood in order to relax and widen the vessel wall and thus, more blood can pass through. However, with age, blood vessels and NO-systems become inefficient due to free radicals, poor diet, etc., causing veins and arteries to deteriorate. It helps in supplying the sufficient amount of blood flow to the tissues and therefore, allows smooth muscles to relax.

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Non-Alcoholic Steatohepatitis

Is a common, often “silent” liver disease. It resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. The major feature in NASH is fat in the liver, along with inflammation and damage. Most individuals with NASH feel well and are not aware that they have a liver problem. Nevertheless, NASH can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly.

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Non-Alcoholic-Fatty-Liver-Disease

is defined as the presence of fat in the liver ( with > 5,5% of liver cells being fatty, hepatic steatosis) after the excluding secondary causes of fat accumulation in the liver (e.g. significant alcohol consumption, certain medications, and other medical conditions). NAFLD occurs when the liver has problems breaking down lipids, causing fat to build up in the liver tissue. NAFLD is now the most common chronic liver disease in high-income countries, and it is estimated to affect at least 25%–40% of the general population. It can progress from simple steatosis to non-alcoholic steatohepatitis (NASH) and hepatic fibrosis to liver cancer.

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