Glossary

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Term Definition
Mediterranean drinking pattern

is defined as moderate intake of alcoholic beverages, with wine preference (≥80% of alcohol consumed as wine) and drinking only with meals.

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Mendelian Randomization

the basic idea of the Mendelian randomization is to use genetic variables as instrumental variables, i.e., genes associated with an exposure (in this study, alcohol consumption or alcohol metabolism) but not directly related to outcome (in this study, HDL-cholesterol and other lipid parameters).  Since the genetic pattern is determined before birth, it should not (at least, in theory) be confounded by later lifestyle exposures or outcome variables.  Thus, it allows the investigators to make causal inference.

Mendelian randomization provides an approach to addressing questions of causality without many of the typical biases that impact the validity of traditional epidemiologic approaches. While Mendelian randomization studies can provide important suggestive evidence for causal relations between risk factor (consumption of alcoholic beverages in this case) and disease outcome (blood lipid levels), they are not true experiments and are dependent on several assumptions. Evidence from randomized controlled trials, when possible, should continue to guide clinical decisions.

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Meta-analysis

is a method of summarizing the results of the same research purpose and comprehensively evaluating its combined effect. It can be an objective, systematic, comprehensive, qualitative and quantitative statistical analysis. It has functions that improve estimates of effect, construct a general review method for omitting inadequate study conclusions, and reinforce the effectiveness of statistical results to yield more comprehensive and reliable study results that are more representative of the general population.

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Metabolic Equivalent Task

refers to energy expenditure from sports and walking during the week.

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Metabolic syndrome

a cluster of abnormalities including increased abdominal fat, poor ability to use the hormone insulin, high blood pressure and high blood levels of triglycerides.

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Moli Sani

The Moli-sani study (www.moli-sani.org) is a cohort study aiming at evaluating the risk factors (environmental, genetics, bio-molecular) linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease.

Source: http://www.neurodegenerationresearch.eu/cohort/the-moli-sani-study/

More information about the Moli Sani study on our databse: https://www.wineinformationcouncil.eu/index.php?option=com_jak2filter&view=itemlist&Itemid=499&issearch=1&isc=1&searchword=Moli%20sani 

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