05 March 2015 In Cancer
BACKGROUND: Previous epidemiological studies of overall alcohol intake and basal cell carcinoma (BCC) are inconsistent, with some evidence for differences by type of alcoholic beverage. While alcohol may enhance the carcinogenicity of ultraviolet (UV) radiation, this has not been evaluated in existing epidemiological studies. OBJECTIVES: To evaluate alcohol intake in relation to early-onset BCC, and explore potential interactions with UV exposure. METHODS: Basal cell carcinoma cases (n = 380) and controls with benign skin conditions (n = 390) under 40 years of age were identified through Yale Dermatopathology. Participants provided information on lifetime alcohol intake, including type of beverage, during an in-person interview. Self-reported data on indoor tanning and outdoor sunbathing were used to categorize UV exposure. We calculated odds ratios (OR) and 95% confidence intervals (CIs) using unconditional multivariate logistic regression in the full sample and in women only. RESULTS: There was no statistically significant association between lifetime alcohol intake and early-onset BCC overall [above median intake vs. no regular alcohol intake (OR 1.10, 95% CI 0.69-1.73)] or in women only (OR 1.21, 95% CI 0.73-2.01). Similarly, intake of red wine, white wine, beer or spirits and mixed drinks was not associated with early-onset BCC. In exploratory analyses, we saw limited evidence for an interaction (P(interaction) = 0.003), with highest risk for high alcohol and high UV exposures, especially in women, but subgroup risk estimates had wide and overlapping CIs. CONCLUSIONS: Overall, we did not observe any clear association between lifetime alcohol intake and early-onset BCC
03 February 2015 In Latest Scientific News

For the first time, it was demonstrated that moderate consumption of red wine could modulate the inflammatory intestinal response in healthy volunteers.

The potential anti-inflammatory effects of red wine and its bio-active compounds, polyphenols in particular, are subject to continuous investigations. Because of the observed protective effects of wine polyphenols in the inflammatory response (*), it was proposed to use phenolic compounds as an alternative to prevent or treat chronic inflammatory diseases. No in vivo studies have been carried out so far to examine the effects of wine polyphenols on intestinal inflammation.

For the first time, the current Spanish study investigated whether moderate consumption of red wine could modulate the inflammatory intestinal response in vivo. 24 immune markers were analyzed in feces from 34 healthy volunteers before and after consumption of red wine (12% ethanol, 1758 mg/L total polyphenols) for 4 weeks. The results indicated that moderate wine consumption during this time, significantly reduced the concentration of several cytokines among a subgroup of volunteers that exhibited unusually high cytokine values before the intervention. 16 immune markers were decreased to normal values, in particular those that promote initial inflammation. This study showed, for the first time, that moderate consumption of phenolic-rich red wine could modulate the inflammatory intestinal response in vivo.

Muñoz-González I, Espinosa-Martos I, Rodríguez JM, et al. Moderate consumption of red wine can modulate human intestinal inflammatory response. J Agric Food Chem. 2014 Oct 29;62(43):10567-75.

For more information about this article, read the scientific abstract here.

 

(*) Inflammation is a type of nonspecific immune response that defends the body against the constant threat of microorganisms and chemical substances from the environment. All components of the gut participate in the intestinal immune response. The exchange of regulatory signals via the production of immune mediators (such as cytokines, growth factors, etc.) facilitates and amplifies cell interactions and/or activates inflammation. These mediators play an important role in the modulation of the intestinal immune system. Chronic intestinal inflammation primarily involves a dysfunction of the intestinal mucosa and an overproduction of the pro-inflammatory mediators.

23 January 2015 In General Health

In this study, 24 immune markers were analyzed in feces from healthy volunteers (n = 34) before and after consumption of a red wine (12% ethanol, 1758 mg/L total polyphenols) for 4 weeks. Analysis of the data permitted the differentiation of a six-volunteer subgroup showing unusually high basal values of cytokines. For this subgroup, consumption of wine significantly (P < 0.05) reduced the content of 16 markers to usual values, especially noticeable for those cytokines that promote initial inflammation (TNF-alpha, IL-6, and IFN-gamma). On the contrary, no significant differences in the concentration of any immune marker were observed after wine consumption for the rest of the volunteers. Additionally, significant and negative correlations among cytokines IFN-gamma, IL-8, and IL-6 and the total fecal content of phenolic metabolites were found for the high-cytokines-values subgroup, before wine intake. This study shows, for the first time, that moderate consumption of red wine could modulate inflammatory intestinal response in vivo.

04 December 2014 In Phenolic compounds

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural polyphenolic compound that exists in Polygonum cuspidatum, grapes, peanuts and berries, as well as their manufactured products, especially red wine. Resveratrol is a pharmacologically active compound that interacts with multiple targets in a variety of cardiovascular disease models to exert protective effects or induce a reduction in cardiovascular risks parameters. This review attempts to primarily serve to summarize the current research findings regarding the putative cardioprotective effects of resveratrol and the molecular pathways underlying these effects. One intent is to hopefully provide a relatively comprehensive resource for clues that may prompt ideas for additional mechanistic studies which might further elucidate and strengthen the role of the stilbene family of compounds in cardiovascular disease and cardioprotection. Model systems that incorporate a significant functional association with tissues outside of the cardiovascular system proper, such as adipose (cell culture, obesity models) and pancreatic (diabetes) tissues, were reviewed, and the molecular pathways and/or targets related to these models and influenced by resveratrol are discussed. Because the body of work encompassing the stilbenes and other phytochemicals in the context of longevity and the ability to presumably mitigate a plethora of afflictions is replete with conflicting information and controversy, especially so with respect to the human response, we tried to remain as neutral as possible in compiling and presenting the more current data with minimal commentary, permitting the reader free reign to extract the knowledge most helpful to their own investigations.

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