24 June 2019 In Cancer

Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a combined analysis of 16 studies of CRC to examine the shape of the alcohol-CRC association, investigate potential effect modifiers of the association, and examine differential effects of alcohol consumption by cancer anatomic site and stage. We collected information on alcohol consumption for 14,276 CRC cases and 15,802 controls from 5 case-control and 11 nested case-control studies of CRC. We compared adjusted logistic regression models with linear and restricted cubic splines to select a model that best fit the association between alcohol consumption and CRC. Study-specific results were pooled using fixed-effects meta-analysis. Compared to non-/occasional drinking (</=1 g/day), light/moderate drinking (up to 2 drinks/day) was associated with a decreased risk of CRC (odds ratio [OR]: 0.92, 95% confidence interval [CI]: 0.88-0.98, p = 0.005), heavy drinking (2-3 drinks/day) was not significantly associated with CRC risk (OR: 1.11, 95% CI: 0.99-1.24, p = 0.08) and very heavy drinking (more than 3 drinks/day) was associated with a significant increased risk (OR: 1.25, 95% CI: 1.11-1.40, p < 0.001). We observed no evidence of interactions with lifestyle risk factors or of differences by cancer site or stage. These results provide further evidence that there is a J-shaped association between alcohol consumption and CRC risk. This overall pattern was not significantly modified by other CRC risk factors and there was no effect heterogeneity by tumor site or stage.

28 October 2014 In Latest Scientific News

A Chinese meta-analysis of prospective studies supports a J-shaped dose-risk association between the consumption of alcoholic beverages and colon cancer; however, heavy alcohol drinking is associated with an increased colon cancer mortality.

There is a widespread acceptance that consumption of alcoholic beverages and colorectal cancer (CRC) are causally related. However, the quantitative association between alcohol drinking and CRC mortality is still an open question. Chinese researchers carried out a systemic review and meta-analysis on epidemiological studies to quantify the risk for CRC mortality at different levels of drinking. Nine suitable cohort studies were identified. It was demonstrated that compared to non/occasional drinkers, the pooled relative risk was 1.03 for any, 0.97 for light (≤12.5 g/day of ethanol), 1.04 for moderate (12.6-49.9 g/day of ethanol), and 1.21 for heavy drinkers (≥50 g/day of ethanol) (a relative risk of 1.21 means a 21% increased risk compared to non-drinkers). The higher risk for heavy drinkers was only apparent for men (RR=1.28) whereas there was an inverse trend for women (RR=0.79). The dose-response analysis showed a J-shaped relationship between alcohol consumption and CRC mortality. 

Cai S, Li Y, Ding Y, Chen K, Jin M. Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. Eur J Cancer Prev. 2014 Aug 28.

For more information about this article, read the scientific abstract here.





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