The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

BACKGROUND: There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. METHODS: Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrollment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. RESULTS: The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (=1 and =0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used

Additional Info

  • Authors:

    Bergmann,M.M.; Rehm,J.; Klipstein-Grobusch,K.; Boeing,H.; Schutze,M.; Drogan,D.; Overvad,K.; Tjonneland,A.; Halkjaer,J.; Fagherazzi,G.; Boutron-Ruault,M.C.; Clavel-Chapelon,F.; Teucher,B.; Kaaks,R.; Trichopoulou,A.; Benetou,V.; Trichopoulos,D.; Palli,D.; Pala,V.; Tumino,R.; Vineis,P.; Beulens,J.W.; Redondo,M.L.; Duell,E.J.; Molina-Montes,E.; Navarro,C.; Barricarte,A.; Arriola,L.; Allen,N.E.; Crowe,F.L.; Khaw,K.T.; Wareham,N.; Romaguera,D.; Wark,P.A.; Romieu,I.; Nunes,L.; Riboli,E.; Ferrari,P.

  • Issue: Int.J.Epidemiol. / pages 1772-1790 / volume 42
  • Published Date: 2013/12
  • More Information:

    For more information about this absctract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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