Friday, 22 October 2021 13:43

A limitation of genetic epidemiological analysis when associations are genuinely J-shaped illustrated using a prospective study of alcohol consumption and vascular disease

Mendelian randomization, a commonly adopted approach in genetic epidemiology, is of value in distinguishing causal from non-causal associations. There are, however, limitations to the conclusions that can be drawn from this approach when the underlying relationship between an outcome and an exposure is non-linear. In this paper we explore a consequence of these limitations, illustrating these using a prospective epidemiological study of vascular disease in 500 000 Chinese people (the Kadoorie cohort).

Additional Info

  • Authors:

    Frost, C.;Wald, N.

  • Issue: Int J Epidemiol . 2021 Sep 25;dyab162.
  • Published Date: 2021 Sep 25
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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