Trajectories of alcohol consumption during life and the risk of developing breast cancer

BACKGROUND: Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. OBJECTIVE: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC).

METHODS: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime.

RESULTS: Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (/=15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, >/=15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.

CONCLUSIONS: The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.

Additional Info

  • Authors:

    Donat-Vargas, C.;Guerrero-Zotano, A.;Casas, A.;Baena-Canada, J. M.;Lope, V.;Antolin, S.;Garcia-Saenz, J. A.;Bermejo, B.;Munoz, M.;Ramos, M.;de Juan, A.;Jara Sanchez, C.;Sanchez-Rovira, P.;Anton, A.;Brunet, J.;Gavila, J.;Salvador, J.;Arriola Arellano, E.;Bezares, S.;Fernandez de Larrea-Baz, N.;Perez-Gomez, B.;Martin, M.;Pollan, M.

  • Issue: Br J Cancer . 2021 Oct;125(8):1168-1176
  • Published Date: 2021 Oct
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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