The microbial metabolite desaminotyrosine protects from influenza through type I interferon

The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the microbiota exert effects through type I interferon (IFN), a hypothesis supported by analysis of influenza in a gain-of-function genetic mouse model. Here we show that a microbially associated metabolite, desaminotyrosine (DAT), protects from influenza through augmentation of type I IFN signaling and diminution of lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice. DAT protected the host by priming the amplification loop of type I IFN signaling. These findings show that specific components of the enteric microbiota have distal effects on responses to lethal infections through modulation of type I IFN.

Additional Info

  • Authors:

    Steed, A. L.;Christophi, G. P.;Kaiko, G. E.;Sun, L.;Goodwin, V. M.;Jain, U.;Esaulova, E.;Artyomov, M. N.;Morales, D. J.;Holtzman, M. J.;Boon, A. C. M.;Lenschow, D. J.;Stappenbeck, T. S.

  • Issue: Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336.
  • Published Date: 2017 Aug 4
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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