A pooled analysis of alcohol intake and colorectal cancer

OBJECT: In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies.

METHOD: Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before July 2014. Data were extracted independently by two reviewers. Random effects meta-analyses, subgroup analyses, and meta regression were performed for modeling the dose-response relation.

RESULT: The pooled relative risk (RR) for any alcohol intake compared with non/occasional drinking was 1.13 [95% confidence interval (CI), 1.09-1.17]. The RRs were 1.07 (95% CI, 1.02-1.13), 1.23 (95% CI, 1.15-1.32) and 1.37 (95% CI, 1.26-1.49) for light (/=50 g/day), respectively. The risks were consistent in the subgroup analyses of sex and tumor site.

CONCLUSION: This meta-analysis provides strong evidence for an association between alcohol intake and colorectal cancer risk.

Additional Info

  • Authors:

    Wang,Y.; Duan,H.; Yang,H.; Lin,J.

  • Issue: Int.J Clin.Exp.Med. / pages 6878-6889
  • Published Date: 2015
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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