Monday, 11 May 2015 08:07

Alcohol and Incident Heart Failure Among Middle-Aged and Elderly Men: The Cohort of Swedish Men

BACKGROUND: -Compared with no alcohol consumption, heavy alcohol intake is associated with a higher rate of heart failure (HF) whereas light-to-moderate intake may be associated with a lower rate. However, several prior studies did not exclude former drinkers, who may have changed alcohol consumption in response to diagnosis. This study aimed to investigate the association between alcohol intake and incident HF.

METHODS AND RESULTS: -We conducted a prospective cohort study of 33,760 men 45-79 years old with no HF, diabetes mellitus or myocardial infarction at baseline participating in the Cohort of Swedish Men Study. We excluded former drinkers. At baseline, participants completed a food-frequency questionnaire and reported other characteristics. HF was defined as hospitalization for or death from HF, ascertained by Swedish inpatient and cause-of-death records from January 1, 1998 through December 31, 2011. We constructed Cox proportional hazards models to estimate multivariable-adjusted rate ratios (IRRs). During follow-up, 2916 men were hospitalized for (n=2139) or died (n=777) of incident HF. There was a U-shaped relationship between total alcohol intake and incident HF (p=0.0004). There was a nadir at light-to-moderate alcohol intake: consuming 7 to less than 14 standard drinks per week was associated with a 19% lower multivariable-adjusted rate of HF compared with never drinking (IRR: 0.81, 95% CI: 0.69, 0.96).

CONCLUSIONS: -In this cohort of Swedish men, there was a U-shaped relationship between alcohol consumption and HF incidence, with a nadir at light-to-moderate intake. Heavy intake did not appear protective.

Additional Info

  • Authors:

    Dorans,K.S.; Mostofsky,E.; Levitan,E.B.; Hakansson,N.; Wolk,A.; Mittleman,M.A.

  • Issue: Circ Heart Fail. 2015 Apr 14. pii: CIRCHEARTFAILURE.114.001787. [Epub ahead of print]
  • Published Date: 2015/4/14
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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