Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis

OBJECTIVE: To clarify the dose-response relationship between alcohol consumption and type 2 diabetes.

RESEARCH DESIGN AND METHODS: A systematic computer-assisted and hand search was conducted to identify relevant articles with longitudinal design and quantitative measurement of alcohol consumption. Adjustment was made for the sick-quitter effect. We used fractional polynomials in a meta-regression to determine the dose-response relationships by sex and end point using lifetime abstainers as the reference group.

RESULTS: The search revealed 20 cohort studies that met our inclusion criteria. A U-shaped relationship was found for both sexes. Compared with lifetime abstainers, the relative risk (RR) for type 2 diabetes among men was most protective when consuming 22 g/day alcohol (RR 0.87 [95% CI 0.76-1.00]) and became deleterious at just over 60 g/day alcohol (1.01 [0.71-1.44]). Among women, consumption of 24 g/day alcohol was most protective (0.60 [0.52-0.69]) and became deleterious at about 50 g/day alcohol (1.02 [0.83-1.26]).

CONCLUSIONS: Our analysis confirms previous research findings that moderate alcohol consumption is protective for type 2 diabetes in men and women.

Additional Info

  • Authors:

    Baliunas,D.O.; Taylor,B.J.; Irving,H.; Roerecke,M.; Patra,J.; Mohapatra,S.; Rehm,J.

  • Issue: Diabetes Care / pages 2123-2132 / volume 32
  • Published Date: 2009/11
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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